According to a recent security firm study - up to 80% of all attacks exploiting vulnerabilities in Q4 2009 were all exploited vulnerabilities in Adobe Reader and Acrobat. This sounds a bit much but it is still a sign from statistics that attackers have been favoring pdf exploits.
It is also a good time to check as see if your system even needs Flash or other 3rd party applications. I have seen Flash and Reader installed on multiple company's server in the past - and I'm not talking about a media server. Do not install Flash on a system that does not require it. In most cases it is only a component that enhances a user's browser experience being able to watch videos or view websites that utilize flash. First of all, if it is an important website that your company needs to view usually the site will have a link for non-flash users to browse. Second of all, most people have flash installed to watch Youtube.com videos and other media. Do you really want your employees to be able to cut into their precious productivity time to watch Youtube? Perhaps it doesn't matter because your current IT department is on top of their game and blocks or filters that sort of web content; then please assess as to why Flash is still installed on your workstations? It may seem as if I am coming off a little harsh, but it is a serious matter when a system is compromised because of a critical vulnerability in an application that could of been easily patched or better yet, properly uninstalled so the service is not even available to be exploited in the first place. To easily see if you have Adobe Flash installed visit: http://isflashinstalled.com/
In addition to Adobe Flash player, Adobe also released critical updates to fix vulnerabilities in product installations of:
Remember: Attackers only need one unpatched program to compromise your system